Perfusion defect size predicts engraftment but not early retention of intra-myocardially injected cardiosphere-derived cells after acute myocardial infarction
نویسندگان
چکیده
منابع مشابه
Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction.
RATIONALE The success of cardiac stem cell therapies is limited by low cell retention, due at least in part to washout via coronary veins. OBJECTIVE We sought to counter the efflux of transplanted cells by rendering them magnetically responsive and imposing an external magnetic field on the heart during and immediately after injection. METHODS AND RESULTS Cardiosphere-derived cells (CDCs) w...
متن کاملEnhancing retention and efficacy of cardiosphere-derived cells administered after myocardial infarction using a hyaluronan-gelatin hydrogel
Cardiosphere-derived cells (CDCs) are under clinical development and are currently being tested in a clinical trial enrolling patients who have undergone a myocardial infarction. CDCs are presently administered via infusion into the infarct-related artery and have been shown in early clinical trials to be effective agents of myocardial regeneration. This review describes the administration of C...
متن کامل[Changes in myocardial function and perfusion after acute myocardial infarction].
Rev Esp Cardiol 2003;56(5):433-5 433 Ligation of a coronary artery causes myocardial necrosis. It has been shown in experimental animals1 that the size of the necrotic scar is directly proportional to the time elapsed between ligation and reperfusion. Early reperfusion not only reduces the size of the infarct, but also protects against ventricular dilatation. Although delayed reperfusion is una...
متن کاملLeft Ventricular Size after Acute Myocardial Infarction
The distance from the midline to the left heart border measured in a standardized manner on calibrated chest roentgenograms was determined serially in 125 patients after acute myocardial infarction. This external left heart dimension (LHD) was compared to the normal value, and its prognostic value was assessed during early and late follow-up periods (average 10, range 2-31 months). Within 96 ho...
متن کاملIntravenous myocardial contrast echocardiography predicts recovery of dysynergic myocardium early after acute myocardial infarction.
OBJECTIVES We aimed to ascertain whether triggered intravenous myocardial contrast echocardiography (MCE) can predict functional recovery in patients with acute myocardial infarction (AMI) and to determine the optimal triggering interval in this setting. BACKGROUND Detection of myocardial viability early after AMI has both therapeutic and prognostic implications. Myocardial contrast echocardi...
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ژورنال
عنوان ژورنال: Basic Research in Cardiology
سال: 2011
ISSN: 0300-8428,1435-1803
DOI: 10.1007/s00395-011-0197-5